We seek a highly motivated postdoctoral fellow to study the role of epitranscriptomics or messenger RNA modification in human disease. Post-transcriptional modification on mRNA has emerged as an essential gene regulatory mechanism. My lab focuses on the most abundant mRNA modification, namely N6-methyladenosine or m6A. We identified a protein complex that governs m6A formation (Nature Cell Biology 16 (2): 191-8, Feb. 2014). Using loss-of-function studies, we reported the requirement of m6A in brain development (Nature Neuroscience 21 (2): 195-206, Feb. 2018). Mechanistically, we discovered
that m6A regulates gene expression via shortening mRNA half-life or crosstalk with histone modifications. Currently, we are investigating roles of m6A mRNA modification in cancer and in neurological disorders using a combination of mouse genetics, biochemistry, cell biology, and high throughout sequencing technologies.